Patients in Study I who did not achieve an erection with >60% rigidity at the base of the penis at 70 min after dosing were assigned a default onset time of 70 min and a default value of 0 for duration of erection in the calculation of means and medians o

Patients in Study I who did not achieve an erection with >60% rigidity at the base of the penis at 70 min after dosing were assigned a default onset time of 70 min and a default value of 0 for duration of erection in the calculation of means and medians o

In the second study, fasted patients received four treatments and underwent four assessments. Visual sexual stimulation (VSS) began 10 min after dosing with study medication and lasted for 60 min. The ability to achieve penile erection is dependent on several factors, including relaxation of corpus cavernosal smooth muscle, increased vascular blood inflow and restricted venous outflow in the penis 1 The physiological mechanism is mediated via a nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway 2 - 4 During stimulation, nonadrenergic-noncholinergic neurones and vascular endothelial cells release NO, which activates guanylate cyclase, thereby increasing the level of cGMP in the corpus cavernosum 2.

 

When VSS began 4 h postdose, the median duration was 5 min (0-45) for Cenforce compared with 0 min for placebo (0-27). Of the patients who achieved >60% penile rigidity after Cenforce, 86% had done so by 30 min after dosing. Patients not achieving >60% penile rigidity by 70 min postdose as measured by a RigiScan® monitoring device were assigned an onset time of 70 min.

 

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